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- Dedication
- Introduction
- Contents
- Part I: General Considerations
- Part II: Traumatic Brain Injury
- Chapter 3: Oxidative Damage Mechanisms in Traumatic Brain Injury and Antioxidant Neuroprotective Approaches
- 3.1 Introduction
- 3.2 Reactive Oxygen Species and Reactive Nitrogen Species
- 3.3 Lipid Peroxidation
- 3.4 Free Radical-Induced Protein Carbonylation and Nitration
- 3.5 Interaction of Oxidative Damage with Other Secondary Injury Mechanisms
- 3.6 Mechanisms for Pharmacological Inhibition of Oxidative Damage
- 3.7 Neuroprotective Effects of Pharmacological Antioxidants in TBI Patients and Models
- 3.8 Combination Antioxidant Treatment of Traumatic Brain Injury
- References
- Chapter 4: Mitochondrial Damage in Traumatic CNS Injury
- Chapter 5: Neuroprotective Agents Target Molecular Mechanisms of Programmed Cell Death After Traumatic Brain Injury
- Chapter 3: Oxidative Damage Mechanisms in Traumatic Brain Injury and Antioxidant Neuroprotective Approaches
- Part III: Focal Cerebral Ischemia
- Part IV: Transient Global Cerebral Ischemia
- Chapter 7: Apoptosis-Inducing Factor Translocation to Nuclei After Transient Global Ischemia
- Chapter 8: Necroptosis in Cerebral Ischemia
- Chapter 9: Histological and Elemental Changes in Ischemic Stroke
- 9.1 The Photothrombotic Model
- 9.2 Tissue Preparation for X-Ray Fluorescence Imaging
- 9.3 Introduction to Synchrotron-Based X-Ray Fluorescence Imaging
- 9.4 Histopathology
- 9.5 Ischemic Cell Death Is Induced by Excitotoxicity
- 9.6 Elemental Imaging
- 9.7 Results of X-Ray Fluorescence Imaging
- 9.8 Contrasting Elemental Images with the Elementary Dogma of Ischemic Stroke
- 9.9 The Concept of the Ischemic Penumbra
- References
- Part V: Hypoglycemic Neuronal Injury
- Chapter 10: Hypoglycemic Brain Damage
- 10.1 General Comparison of Hypoglycemic and Ischemic Brain Damage
- 10.2 A Brief History of Hypoglycemic Brain Damage
- 10.3 Settings of Hypoglycemic Brain Damage
- 10.4 Delivery of Glucose and Cerebral Blood Flow
- 10.5 Biochemistry of Hypoglycemic Brain Damage
- 10.6 Neuropathology of Hypoglycemic Brain Damage
- 10.7 Electron Microscopy of Hypoglycemic Brain Damage
- References
- Chapter 10: Hypoglycemic Brain Damage
- Part VI: Seizure-Induced Neuronal Death
- Chapter 11: Activation of Caspase-Independent Programmed Pathways in Seizure-Induced Neuronal Necrosis
- 11.1 Excitotoxicity and Seizure-Induced Neuronal Death
- 11.2 The Morphology of Cell Death
- 11.3 The Time Course of the Appearance of Necrotic Neurons Following Seizure Onset
- 11.4 Apoptosis and the Caspase-Dependent Pathways of Cell Death
- 11.5 Caspase-Independent Programmed Mechanisms in Necrotic Cell Death
- 11.6 Translating an Understanding of Mechanisms to a Neuroprotective Strategy in Refractory Human Status Epilepticus
- References
- Chapter 11: Activation of Caspase-Independent Programmed Pathways in Seizure-Induced Neuronal Necrosis
- Concluding Remarks
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